There are about 14 million Americans who have cancer, according to the National Cancer Institute. It's so common that most of us have a relative--or, sometimes, several--who've had one type or another. What we may not realize, though, is that some cancers are can be caused by genetic mutations that are hereditary, increasing the risk that many family members will develop the disease.
Sounds scary, right? But before you panic, there are several things you need to know. First, as far as scientists know, not all cancers can be traced to inherited genetic mutations. Second, you need to do a little sleuthing into your and your extended family's history. And, finally, if you do suspect that cancer is hereditary, you need to take action.
To help us sort all of this out, we went to Theodora Ross, M.D., an oncologist and the director of the Cancer Genetics Program at the University of Texas Southwestern Medical Center. Not only is she an expert, but she's got personal experience: She carries a genetic mutation that increases her risk of breast and ovarian cancer. She's also the author of A Cancer in the Family: Take Control of Your Genetic Inheritance, out in February.
All cancers are caused by genetic mutations, but not all genetic mutations are inherited.
When the genes that suppress tumors don't function correctly, cells divide uncontrollably, form cancerous tumors, and, if not treated, spread throughout the body. That's what we call cancer. Often, these genes turn faulty because of some environmental factor (think smoking). Other times, you inherit a copy from your parents or grandparents. That's an inherited mutation.
Several of the most common cancers can be attributed to inherited mutations.
"Ovarian, breast, pancreas, stomach, colon, prostate, endometrial, kidney, and melanoma skin cancers are thought to have a significant inherited piece," says Dr. Ross. There are other rarer cancers too. Some genetic mutations, like the ones in BRCA1 and 2 genes, can increase your risk for several types of cancer, including breast, ovarian, pancreatic, prostate, and melanoma.
There are certain clues that tell you whether cancer is hereditary.
"If your dad was a heavy smoker who died of lung cancer, it’s a good bet that the cancer he died from was environmentally caused rather than caused by a large inherited component," says Dr. Ross. But watch for these signs: Several close family members were diagnosed with cancer before age 50; multiple family members have the same type of cancer (say, pancreatic or breast); there are many cases of a rare cancer (medullary thyroid cancers) in the family; relatives have gotten cancer in both pairs of organs (both breasts, both ovaries, both kidneys).
Take a look at the family connection.
If your mom and grandmother both had breast cancer that's more cause for concern than a cousin or aunt. Just be aware that mutations can skip a generation, says Dr. Ross.
Certain genetic mutations run in ethnic groups.
For example, if you're Jewish and your ancestors came from Germany, Russia, or Eastern Europe, you have a higher risk of having mutations in the BRCA1 and 2 genes. Hispanics and African-Americans have a higher risk of developing colon cancer--and at a younger age--than Caucasians.
Act like a detective.
Relatives don't like to share medical information--and the older they are, the less likely they are to talk. Or as Dr. Ross puts it, "Having cancer conversations with family brings out the crazies in all of us. Just knowing that helps you tolerate the crazies." Start by writing down medical information about every close family member, beginning with yourself. Then, at family gatherings, collect information in a casual way, by asking relatives for stories about their life rather than grilling them. Then go home and record the information (or do it on the spot).
Not everyone needs genetic testing.
If there is a strong family history and you are Hispanic, for example, then it may be worth your while to be tested for a particular mutation, says Dr. Ross. But testing all your genes to find out all your mutation may not be such a good idea. "They say that a third of cancers are inherited but we only know about 5 to 10 percent of cancers with specific genes. Without knowing where to look, the results are hard to interpret."
Insurance will cover testing, if there's a strong family history of cancer.
But get it done professionally, so a genetic counselor can walk you through the interpretation, the risks, and management. Don't send away for a home kit! They're not reliable and you may not be able to sift through the results; all of us have genetic mutations, about 800 of them, according to Dr. Ross.
Even if cancer runs in your family, biology is not destiny.
"Your level of risk depends on the gene, the mutation AND the family history," says Dr. Ross. "BRCA1, BRCA2, TP53, and Lynch Syndrome gene mutations (MLH1, MSH2, MSH6, PMS2,) are considered high risk. However, the number of cancers in the family and the ages these relatives were diagnosed predicts if others in the family with the shared mutation will develop the cancer." In other words, there's a range of risk--and a genetic counselor can help you sort through it and what to do. If you know you carry the BRCA1/2 mutation, and several close relatives have gotten breast cancer, you can go the Angelina Jolie route and have your breasts and ovaries removed. Or even your pancreas if that type of cancer runs in your family.
Get every single annual exam insurance covers..
Screening tests and exams save lives by catching cancer early on, when it's most treatable. If melanoma runs in your family, don't skip skin checks. If ovarian/breast cancer is common among your relatives, that annual visit to the gynecologist is another must-make.
Swap in some good habits.
Bad habits, like eating unhealthy foods or smoking, can further drive up your risk. The opposite is always true, so make certain lifestyle changes. Taking a low-dose aspirin can lower your chances of colon cancer, for instance, as can cutting back on red meat (especially if it's smoked). Exercise and a diet rich in fruits and vegetables is a good idea for anyone, but especially those who have cancer in their family tree.
Throughout 2016, FirstforWomen.com will be telling you EXACTLY what you should do if nine types of common cancers, from pancreatic to breast, run in your family. Check back for more specific info on what your options are to taking control of your health.
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